Gene therapies will provide a valid treatment option for patients that have developed resistance to chemotherapies across several cancer indications. With patient access set to increase over the next decade, these therapies are expected to eliminate the need for further treatments and reduce the cost of disease management. Total sales of in-vivo gene therapies are forecast to reach over $7bn by 2027 across the 8MM*, with the therapeutic oligonucleotide market forecast to reach $4.5bn by 2027 globally.
Scope
Overview of gene therapy including classification of therapy and technologies, regulatory and market access details, product & company profiles.
Quotes from US- and 5EU-based key opinion leaders and researchers.
Key topics covered for gene therapy in oncology in the 8MM include trends, value chain, market analysis, opportunities, challenges and unmet needs and high-value deals.
Pipeline analysis: Comprehensive data split across different phases and indications, emerging novel trends under development, and analysis of the most promising late-stage pipeline drugs for classes of gene therapy (Phase III and pre-registration).
Analysis of the key dynamics of the gene therapy market. Insightful review of the key industry drivers and challenges. Deals and R&D strategies covered in detail to highlight business opportunities.
Key Questions Answered
What are the late-stage gene therapy pipeline agents in development for cancer? Which class of gene therapy drugs will have the highest peak sales, and why?
What are the current unmet needs that gene therapies can address in the treatment of cancer? What are the opportunities for R&D?
How is the field of gene therapy going to move forward? Which technologies are the most promising for combinations?
What is the regulatory landscape for gene therapies in the US, the 5EU, Japan and China?
Key Highlights
The main drivers of growth include significant industrial investment in the field, as well as regulatory bodies’ recognition of gene therapy potential by creating specialized designations for gene therapy products.
The main barriers to growth include market access issues such as high cost of therapy/lack of reimbursement and lack of expertise as well as clinical issues such as safety concerns.
The most important unmet needs in the oncology gene therapy market include high cost of therapy, improving the safety of delivery systems and providing a valid treatment option to treat several cancer types.
The 8MM have set up programs to expedite gene therapy approvals, especially when they address an unmet need or are targeting orphan indications.
Reasons to buy
The report will enable you to:
Develop and design your in-licensing and out-licensing strategies, using a detailed overview of current deals and technologies to identify companies with the highest potential.
Develop business strategies by understanding the trends shaping and driving the global oncology gene therapy market.
Drive revenues by understanding the key trends, innovative products and technologies, market segments, and companies likely to impact the global oncology gene therapy market in the future.
Design your development strategy through a review of potential novel targets or combinations across indications.
Understand the challenges and strategies impacting the development of oncology gene therapy agents in preclinical studies and clinical trials.
Identify emerging players with potentially strong product portfolios and create effective counter-strategies to gain a competitive advantage.
Organize your sales and marketing efforts by identifying the classes of gene therapy and indications that present maximum opportunities for consolidations, investments and strategic partnerships.
Amgen
Candel
CG Oncology
Checkmate
Daiichi Sankyo
Ferring
FKD
Geron
Idera
Istari
SiBiono
Sunway Biotech
VBL
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1. Preface
1.1. Table of Contents
1.2. Abbreviations
1.3. Related Reports
2. Executive Summary
2.1. Key Findings
3. Gene Therapy Overview
3.1. What is Gene Therapy?
3.2. History of Gene Therapy Development in Cancer in the 8MM
3.3. Key Twitter Chat
4. Trends
4.1. Industry Trends – Gene Therapy Vectors
4.2. Industry Trends – Therapeutic Oligonucleotides
4.3. Industry Trends – Genome Editing
4.4. Industry Trends – Oncolytic Viruses
4.5. Regulatory Trends
5. Value Chain
5.1. Gene Therapy Value Chain
5.2. Gene Therapy Vectors
5.3. Therapeutic Oligonucleotides
5.4. Genome Editing
5.5. Oncolytic Viruses
5.6. Gene Therapy in Oncology Clinical Trials
6. Marketed Products
6.1. Marketed Gene Therapy Products for Cancer in the 8MM
6.2. Leading Gene Therapy Treatments in The 8MM
7. Pipeline Products
7.1. Gene Therapy Pipeline Products in the 8MM
7.2. Gene Therapy Pipeline Candidates
7.3. Late Stage Gene Therapy Candidates, 8MM
8. Market Analysis and Deals
8.1. Gene Therapy Market Analysis and Forecast by Class of Therapy
8.2. Top 10 Transaction Deals by Size during 2012-2021 in the Oncology Gene Therapy Space
8.3. Latest Transaction Deals in the Oncology Gene Therapy Space
8.4. Mergers and Acquisitions That Include Oncology Gene Therapy Assets: 2019 – 2021
8.5. Mergers and Acquisitions That Include Oncology Gene Therapy Assets: 2014 – 2018
9. Regulatory and Market Access
9.1. Gene Therapy in Clinical Trials
9.2. Regulatory – US
9.3. Market Access – US
9.4. Regulatory – Europe
9.5. Market Access – Europe
9.6. Regulation of Gene Therapy in the US and Europe
9.7. Regulatory and Market Access – Japan
9.8. Comparison of Early Access Schemes in the US, EU, and Japan
9.9. Regulatory and Market Access – China
10. Opportunities, Challenges, and Unmet Needs
10.1. Gene Therapy Vectors, Viral – Opportunities & Challenges
10.2. Gene Therapy Vectors, Non-viral – Opportunities & Challenges
10.3. Therapuetic Oligonucleotides – Opportunities & Challenges
10.4. Genome Editing – Opportunities & Challenges
10.5. Oncolytic Viruses – Opportunities & Challenges
10.6. Clinical Unmet Needs in Gene Therapy – Gap Analysis
10.7. Commercial Unmet Needs in Gene Therapy – Gap Analysis
10.8. Unmet Needs – KOLs Perspective
11. Companies
11.1. Drug Development Scorecard – Regenerative Medicine
11.2. Current Major Players
11.2.1. Amgen
11.2.2. SiBiono
11.2.3. Sunway Biotech
11.3. Future Players Based on Pipeline Strength
11.3.1. Candel
11.3.2. CG Oncology
11.3.3. Checkmate
11.3.4. Daiichi Sankyo
11.3.5. Ferring
11.3.6. FKD
11.3.7. Geron
11.3.8. Idera
11.3.9. Istari
11.3.10. VBL
12. Appendix
12.1. Bibliography
12.2. Primary Research
12.3. Key Themes Impacting the Pharmaceutical Industry
12.4. Our Thematic Research Methodology
12.5. About the Authors
12.6. Contact Us
12.7. Disclaimer
