TABLE OF CONTENTS I
LIST OF FIGURES IX
LIST OF CHARTS XI
EXECUTIVE SUMMARY 1
U.S. NEUROMODULATION, NEUROVASCULAR, NEUROSURGICAL AND MONITORING DEVICE MARKET OVERVIEW 1
COMPETITIVE ANALYSIS 4
MARKET TRENDS 8
MARKET DEVELOPMENTS 11
PROCEDURE NUMBERS 12
PROCEDURE CODES INVESTIGATED 13
MARKETS INCLUDED 15
KEY REPORT UPDATES 17
VERSION HISTORY 17
RESEARCH METHODOLOGY 18
1.1 RESEARCH SCOPE 18
1.2 IDATA’S 9-STEP METHODOLOGY 18
Step 1: Project Initiation & Team Selection 18
Step 2: Prepare Data Systems and Perform Secondary Research 20
Step 3: Preparation for Interviews & Questionnaire Design 21
Step 4: Performing Primary Research 22
Step 5: Research Analysis: Establishing Baseline Estimates 24
Step 6: Market Forecast and Analysis 25
Step 7: Identify Strategic Opportunities 27
Step 8: Final Review and Market Release 28
Step 9: Customer Feedback and Market Monitoring 29
DISEASE OVERVIEW 30
2.1 BASIC ANATOMY 30
2.2 DISEASE PATHOLOGY AND DISORDERS 32
2.2.1 Introduction 32
2.2.2 General Diagnostics and Neurosurgery 34
2.2.3 Tumor and Brain Cancer 36
2.2.4 Brain Arteriovenous Malformations 38
2.2.5 Ischemic Stroke 39
2.2.6 Brain Aneurysm 40
2.2.7 Disorders Related to Cerebrospinal Fluids and Intracranial Pressure 42
2.2.7.1 Hydrocephalus and Intracranial Pressure Disorder 42
2.2.7.2 Cerebral Edema 43
2.2.8 Indication for Neuromodulation 45
2.2.9 Traumatic brain injury 47
PRODUCT ASSESSMENT 48
3.1 PRODUCT PORTFOLIOS 48
3.1.1 Mechanical Thrombectomy 48
3.1.1.1 Introduction 48
3.1.1.2 Product Matrix for Mechanical Trombectomy device: Core Companies 51
3.2 REGULATORY ISSUES AND RECALLS 52
3.2.1 Mechanical Thrombectomy 52
3.3 CLINICAL TRIALS 53
3.3.1 Mechanical Thrombectomy 53
MECHANICAL THROMBECTOMY MARKET 56
4.1 INTRODUCTION 56
4.2 MARKET OVERVIEW 59
4.3 MARKET ANALYSIS AND FORECAST 63
4.3.1 Stent Retrievers 63
4.3.2 Thrombectomy Catheters 65
4.4 DRIVERS AND LIMITERS 67
4.4.1 Market Drivers 67
4.4.2 Market Limiters 68
4.5 COMPETITIVE MARKET SHARE ANALYSIS 69
ABBREVIATIONS 72
APPENDIX: COMPANY PRESS RELEASES 75

Chart 1 1: Neurological Device Market by Segment, U.S., 2013 – 2023 3
Chart 1 2: Neurological Device Market Overview, U.S., 2016 & 2023 3
Chart 4 1: Mechanical Thrombectomy Market by Segment, U.S., 2013 – 2023 61
Chart 4 2: Mechanical Thrombectomy Market Breakdown, U.S., 2016 62
Chart 4 3: Mechanical Thrombectomy Market Breakdown, U.S., 2023 62
Chart 4 4: Stent Retriever Market, U.S., 2013 – 2023 64
Chart 4 5: Thrombectomy Catheter Market, U.S., 2013 – 2023 66
Chart 4 6: Leading Competitors, Mechanical Thrombectomy Market, U.S., 2016 71

Figure 1 1: Neurological Device Market Share Ranking by Segment, U.S., 2016 (1 of 3) 5
Figure 1 2: Neurological Device Market Share Ranking by Segment, U.S., 2016 (2 of 3) 5
Figure 1 3: Neurological Device Market Share Ranking by Segment, U.S., 2016 (3 of 3) 6
Figure 1 4: Companies Researched in this Report, U.S., 2016 7
Figure 1 5: Factors Impacting the Neurological Device Market by Segment, U.S. (1 of 3) 8
Figure 1 6: Factors Impacting the Neurological Device Market by Segment, U.S. (2 of 3) 9
Figure 1 7: Factors Impacting the Neurological Device Market by Segment, U.S. (3 of 3) 10
Figure 1 8: Recent Events in the Neurological Device Market, U.S., 2014 – 2016 11
Figure 1 9: Neurological Device Markets Covered, U.S., 2016 12
Figure 1 10: Procedural Codes Investigated, U.S., 2016 (1 of 2) 13
Figure 1 11: Procedural Codes Investigated, U.S., 2016 (2 of 2) 14
Figure 1 12: Neurological Device Markets Covered, U.S., 2016 (1 of 2) 15
Figure 1 13: Neurological Device Markets Covered, U.S., 2016 (2 of 2) 16
Figure 1 14: Key Report Updates 17
Figure 1 15: Version History 17
Figure 2 1: Neurology Disease Overview 33
Figure 2 2: Brain/Other Nervous System Cancer Statistics by Type and Gender, U.S., 2016 37
Figure 3 1: Class 2 Device Recall: Trevo Pro 4 Stent Retriever 52
Figure 3 2: Mechanical Trombectomy: Comparison of Thrombectomy and Standard Care for Ischemic Stroke 53
Figure 3 3: Mechanical Trombectomy: Interest of Direct Aspiration First Pass Technique (ADAPT) 53
Figure 3 4: Mechanical Trombectomy: Case Review of the Penumbra and Indigo Systems for Mechanical Thrombectomy 54
Figure 3 5: Mechanical Trombectomy: Evaluation of the ReVive SE Device for Intra-Arterial Thrombectomy in Acute Ischemic Stroke 54
Figure 3 6: Mechanical Trombectomy: Trial and Cost Effectiveness Evaluation of Intra-arterial Thrombectomy 55
Figure 4 1: Mechanical Thrombectomy Market by Segment, U.S., 2013 – 2023 60
Figure 4 2: Stent Retriever Market, U.S., 2013 – 2023 63
Figure 4 3: Thrombectomy Catheter Market, U.S., 2013 – 2023 65
Figure 4 4: Drivers and Limiters, Mechanical Thrombectomy Market, U.S., 2016 68
Figure 4 5: Leading Competitors, Mechanical Thrombectomy Market, U.S., 2016 70
Figure 6 1: Press Release Summary 75

Medtronic
Boston Scientific
St. Jude Medical
Cyberonics
Codman & Shurtleff
Stryker
Integra LifeSciences
InoMed
Mizuho America
RauMedic