TABLE OF CONTENTS I
LIST OF FIGURES IX
LIST OF CHARTS XI
EXECUTIVE SUMMARY 1
U.S. NEUROMODULATION, NEUROVASCULAR, NEUROSURGICAL AND MONITORING DEVICE MARKET OVERVIEW 1
COMPETITIVE ANALYSIS 4
MARKET TRENDS 8
MARKET DEVELOPMENTS 11
PROCEDURE NUMBERS 12
PROCEDURE CODES INVESTIGATED 13
MARKETS INCLUDED 15
KEY REPORT UPDATES 17
VERSION HISTORY 17
RESEARCH METHODOLOGY 18
1.1 RESEARCH SCOPE 18
1.2 IDATA’S 9-STEP METHODOLOGY 18
Step 1: Project Initiation & Team Selection 18
Step 2: Prepare Data Systems and Perform Secondary Research 20
Step 3: Preparation for Interviews & Questionnaire Design 21
Step 4: Performing Primary Research 22
Step 5: Research Analysis: Establishing Baseline Estimates 24
Step 6: Market Forecast and Analysis 25
Step 7: Identify Strategic Opportunities 27
Step 8: Final Review and Market Release 28
Step 9: Customer Feedback and Market Monitoring 29
DISEASE OVERVIEW 30
2.1 BASIC ANATOMY 30
2.2 DISEASE PATHOLOGY AND DISORDERS 32
2.2.1 Introduction 32
2.2.2 General Diagnostics and Neurosurgery 34
2.2.3 Tumor and Brain Cancer 36
2.2.4 Brain Arteriovenous Malformations 38
2.2.5 Ischemic Stroke 39
2.2.6 Brain Aneurysm 40
2.2.7 Disorders Related to Cerebrospinal Fluids and Intracranial Pressure 42
2.2.7.1 Hydrocephalus and Intracranial Pressure Disorder 42
2.2.7.2 Cerebral Edema 43
2.2.8 Indication for Neuromodulation 45
2.2.9 Traumatic brain injury 47
PRODUCT ASSESSMENT 48
3.1 PRODUCT PORTFOLIOS 48
3.1.1 Aneurysm Clip 48
3.1.1.1 Introduction 48
3.1.1.2 Product Matrix for Aneurysm Clip Device: Core Companies 50
3.2 REGULATORY ISSUES AND RECALLS 51
3.2.1 Aneurysm Clip 51
3.3 CLINICAL TRIALS 52
3.3.1 Aneurysm Clip 52
ANEURYSM CLIP MARKET 54
4.1 INTRODUCTION 54
4.2 MARKET ANALYSIS AND FORECAST 56
4.2.1 Aneurysm Clip Market 56
4.2.2 Aneurysm Clip Market by Material 58
4.2.2.1 Titanium Aneurysm Clip Market 58
4.2.2.2 Cobalt Chromium Aneurysm Clip Market 60
4.3 DRIVERS AND LIMITERS 62
4.3.1 Market Drivers 62
4.3.2 Market Limiters 63
4.4 COMPETITIVE MARKET SHARE ANALYSIS 64
ABBREVIATIONS 67
APPENDIX: COMPANY PRESS RELEASES 70

Chart 1 1: Neurological Device Market by Segment, U.S., 2013 – 2023 3
Chart 1 2: Neurological Device Market Overview, U.S., 2016 & 2023 3
Chart 4 1: Aneurysm Clip Market, U.S., 2013 – 2023 57
Chart 4 2: Titanium Aneurysm Clip Market, U.S., 2013 – 2023 59
Chart 4 3: Cobalt Chromium Aneurysm Clip Market, U.S., 2013 – 2023 61
Chart 4 4: Leading Competitors, Aneurysm Clip Market, U.S., 2016 66

Figure 1 1: Neurological Device Market Share Ranking by Segment, U.S., 2016 (1 of 3) 5
Figure 1 2: Neurological Device Market Share Ranking by Segment, U.S., 2016 (2 of 3) 5
Figure 1 3: Neurological Device Market Share Ranking by Segment, U.S., 2016 (3 of 3) 6
Figure 1 4: Companies Researched in this Report, U.S., 2016 7
Figure 1 5: Factors Impacting the Neurological Device Market by Segment, U.S. (1 of 3) 8
Figure 1 6: Factors Impacting the Neurological Device Market by Segment, U.S. (2 of 3) 9
Figure 1 7: Factors Impacting the Neurological Device Market by Segment, U.S. (3 of 3) 10
Figure 1 8: Recent Events in the Neurological Device Market, U.S., 2014 – 2016 11
Figure 1 9: Neurological Device Markets Covered, U.S., 2016 12
Figure 1 10: Procedural Codes Investigated, U.S., 2016 (1 of 2) 13
Figure 1 11: Procedural Codes Investigated, U.S., 2016 (2 of 2) 14
Figure 1 12: Neurological Device Markets Covered, U.S., 2016 (1 of 2) 15
Figure 1 13: Neurological Device Markets Covered, U.S., 2016 (2 of 2) 16
Figure 1 14: Key Report Updates 17
Figure 1 15: Version History 17
Figure 2 1: Neurology Disease Overview 33
Figure 2 2: Brain/Other Nervous System Cancer Statistics by Type and Gender, U.S., 2016 37
Figure 3 1: Class 2 Device Recall: Mizuho Sugita Titanium Standard Aneurysm Clip II Temporary 51
Figure 3 2: Class 2 Device Recall: Casper Clip Appliers, Aesculap Inc. 51
Figure 3 3: Aneurysm Clip: DIVERT: Diversion of Flow in Intracranial VErtebral 52
Figure 3 4: Aneurysm Clip: Rapid Ventricular Pacing in Surgical Treatment of Intracranial Aneurysms 52
Figure 3 5: Aneurysm Clip: Barrow Ruptured Aneurysm Trial (BRAT) 52
Figure 3 6: Aneurysm Clip: Safety Study of Minimally Invasive Approaches 53
Figure 4 1: Aneurysm Clip Market, U.S., 2013 – 2023 56
Figure 4 2: Titanium Aneurysm Clip Market, U.S., 2013 – 2023 58
Figure 4 3: Cobalt Chromium Aneurysm Clip Market, U.S., 2013 – 2023 60
Figure 4 4: Drivers and Limiters, Aneurysm Clip Market, U.S., 2016 63
Figure 4 5: Leading Competitors, Aneurysm Clip Market, U.S., 2016 65
Figure 6 1: Press Release Summary 70

Medtronic
Boston Scientific
St. Jude Medical
Cyberonics
Codman & Shurtleff
Stryker
Integra LifeSciences
InoMed
Mizuho America
RauMedic