General Report Contents
• Market Analyses include: Unit Sales, ASPs, Market Value & Growth Trends
• Market Drivers & Limiters for each chapter segment
• Competitive Analysis for each chapter segment
• Section on recent mergers & acquisitions
There has been much greater interest in bone marrow concentration for use in spinal fusions compared to platelet-rich plasma. The platelet-rich plasma market, on the other hand, is expanding into soft tissue indications. While bone graft substitutes can be soaked in PRP or bone marrow concentrate as an application, the most rapidly growing application, especially for platelet-rich plasma, is for injectables. Such products are directly injected into the site, for example, in a ligament repair or wound operation.
Competition over price is the reason the market values for these segments are not growing as quickly as might be expected. Arthrex significantly brought down the ASP for the market when they introduced their ACP® platelet concentration system, but prices have now largely stabilized in the PRP segment. Test-tube-based products allow for concentration of smaller volumes; these systems reduce ASP further as customers can shift away from higher ASP disposable bucket products.
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TABLE OF CONTENTS I
LIST OF FIGURES XVIII
LIST OF CHARTS XX
EXECUTIVE SUMMARY 1
U.S. ORTHOPEDIC BIOMATERIALS MARKET OVERVIEW 1
COMPETITIVE ANALYSIS 4
MARKET TRENDS 6
MARKET DEVELOPMENTS 8
PROCEDURE NUMBERS 9
MARKETS INCLUDED 11
KEY REPORT UPDATES 13
VERSION HISTORY 13
RESEARCH METHODOLOGY 14
1.1 RESEARCH SCOPE 14
1.2 IDATA’S 9-STEP METHODOLOGY 14
Step 1: Project Initiation & Team Selection 14
Step 2: Prepare Data Systems and Perform Secondary Research 16
Step 3: Preparation for Interviews & Questionnaire Design 17
Step 4: Performing Primary Research 18
Step 5: Research Analysis: Establishing Baseline Estimates 20
Step 6: Market Forecast and Analysis 21
Step 7: Identify Strategic Opportunities 23
Step 8: Final Review and Market Release 24
Step 9: Customer Feedback and Market Monitoring 25
DISEASE OVERVIEW 26
2.1 BASIC ANATOMY 26
2.1.1 Osteology and Musculoskeletal System 26
2.2 DISEASE PATHOLOGY AND DISORDERS 28
2.2.1 General Diagnostic 28
2.2.2 Osteoporosis 29
2.2.3 Osteoarthritis 29
2.2.4 Indication for Bone Graft Procedure 30
2.2.5 Indication for Cartilage Repair 31
2.2.6 Degenerative Disc Disease 32
2.3 PATIENT DEMOGRAPHICS 34
2.3.1 General Statistics 34
PRODUCT ASSESSMENT 36
3.1 PRODUCT PORTFOLIOS 36
3.1.1 Cell Therapy 37
3.2 REGULATORY ISSUES AND RECALLS 41
3.2.1 Cell Therapy 41
3.3 CLINICAL TRIALS 42
3.3.1 Cell Therapies 42
ORTHOPEDIC CELL THERAPY MARKET 44
4.1 INTRODUCTION 44
4.2 MARKET OVERVIEW 48
4.3 MARKET ANALYSIS AND FORECAST 52
4.3.1 Total Platelet-Rich Plasma Market 52
4.3.1.1 Soft Tissue Platelet-Rich Plasma Market 55
4.3.1.2 Orthopedic Platelet-Rich Plasma Market 57
4.3.1.3 Cardiac Platelet-Rich Plasma Market 59
4.3.1.4 Spine Platelet-Rich Plasma Market 61
4.3.1.5 Plastics Platelet-Rich Plasma Market 63
4.3.2 Total Bone Marrow Concentrate Market 65
4.3.2.1 Spine Bone Marrow Concentrate Market 68
4.3.2.2 Trauma Bone Marrow Concentrate Market 70
4.3.2.3 Soft Tissue Concentrated Bone Marrow Aspirate Market 72
4.3.2.4 Joint Concentration Bone Marrow Concentrate Market 74
4.4 DRIVERS AND LIMITERS 76
4.4.1 Market Drivers 76
4.4.2 Market Limiters 77
4.5 COMPETITIVE MARKET SHARE ANALYSIS 79
ABBREVIATIONS 83
APPENDIX II: COMPANY PRESS RELEASES 85
Chart 1 1: Orthopedic Biomaterials Market by Segment, U.S., 2013 – 2023 3
Chart 1 2: Orthopedic Biomaterials Market Overview, U.S., 2016 & 2023 3
Chart 4 1: Orthopedic Cell Therapy Market by Segment, U.S., 2013 – 2023 50
Chart 4 2: Orthopedic Cell Therapy Market Breakdown, U.S., 2016 51
Chart 4 3: Orthopedic Cell Therapy Market Breakdown, U.S., 2023 51
Chart 4 4: Total Platelet-Rich Plasma Market, U.S., 2013 – 2023 54
Chart 4 5: Soft Tissue Platelet-Rich Plasma Market, U.S., 2013 – 2023 56
Chart 4 6: Orthopedic Platelet-Rich Plasma Market, U.S., 2013 – 2023 58
Chart 4 7: Cardiac Platelet-Rich Plasma Market, U.S., 2013 – 2023 60
Chart 4 8: Spine Platelet-Rich Plasma Market, U.S., 2013 – 2023 62
Chart 4 9: Plastics Platelet-Rich Plasma Market, U.S., 2013 – 2023 64
Chart 4 10: Total Bone Marrow Concentrate Market, U.S., 2013 – 2023 67
Chart 4 11: Spine Bone Marrow Concentrate Market, U.S., 2013 – 2023 69
Chart 4 12: Trauma Bone Marrow Concentrate Market, U.S., 2013 – 2023 71
Chart 4 13: Soft Tissue Concentrated Bone Marrow Aspirate Market, U.S., 2013 – 2023 73
Chart 4 14: Joint Concentration Bone Marrow Concentrate Market, U.S., 2013 – 2023 75
Chart 4 15: Leading Competitors, Orthopedic Cell Therapy Market, U.S., 2016 82
Figure 1 1: Orthopedic Biomaterials Market Share Ranking by Segment, U.S., 2016 (1 of 2) 4
Figure 1 2: Orthopedic Biomaterials Market Share Ranking by Segment, U.S., 2016 (2 of 2) 4
Figure 1 3: Companies Researched in this Report, U.S., 2016 5
Figure 1 4: Factors Impacting the Orthopedic Biomaterials Market by Segment, U.S. (1 of 2) 6
Figure 1 5: Factors Impacting the Orthopedic Biomaterials Market by Segment, U.S. (2 of 2) 7
Figure 1 6: Recent Events in the Orthopedic Biomaterials Market, U.S., 2013 – 2016 8
Figure 1 7: Orthopedic Biomaterials Markets Covered, U.S., 2016 (1 of 2) 9
Figure 1 8: Orthopedic Biomaterials Markets Covered, U.S., 2016 (2 of 2) 10
Figure 1 9: Orthopedic Biomaterials Markets Covered, U.S., 2016(1 of 3) 11
Figure 3 1: Cell Therapy Products by Company 40
Figure 3 2: Class 2 Device Recall OnControl 41
Figure 3 3: Class 2 Device Recall Graft Delivery System 41
Figure 3 4: Autologous Bone Marrow Derived Mesenchymal Stromal Cells Transplantation (BM-MSC) for Kienbock's Disease 42
Figure 3 5: The Effect of Platelet Rich Plasma (PRP) on Post Operative Pain in Anterior Cruciate Ligament Reconstruction 42
Figure 3 6: Comparative Assessment of Intra-articular Knee Injections of Platelet-rich Plasma (PRP) and Hyaluronic Acid 43
Figure 3 7: Evaluation of Safety and Exploratory Efficacy of CARTISTEM®, a Cell Therapy Product for Articular Cartilage Defects 43
Figure 4 1: Orthopedic Cell Therapy Market by Segment, U.S., 2013 – 2023 (US$M) 49
Figure 4 2: Total Platelet-Rich Plasma Market, U.S., 2013 – 2023 53
Figure 4 3: Soft Tissue Platelet-Rich Plasma Market, U.S., 2013 – 2023 55
Figure 4 4: Orthopedic Platelet-Rich Plasma Market, U.S., 2013 – 2023 57
Figure 4 5: Cardiac Platelet-Rich Plasma Market, U.S., 2013 – 2023 59
Figure 4 6: Spine Platelet-Rich Plasma Market, U.S., 2013 – 2023 61
Figure 4 7: Plastics Platelet-Rich Plasma Market, U.S., 2013 – 2023 63
Figure 4 8: Total Bone Marrow Concentrate Market, U.S., 2013 – 2023 66
Figure 4 9: Spine Bone Marrow Concentrate Market, U.S., 2013 – 2023 68
Figure 4 10: Trauma Bone Marrow Concentrate Market, U.S., 2013 – 2023 70
Figure 4 11: Soft Tissue Concentrated Bone Marrow Aspirate Market, U.S., 2013 – 2023 72
Figure 4 12: Joint Concentration Bone Marrow Concentrate Market, U.S., 2013 – 2023 74
Figure 4 13: Drivers and Limiters, Orthopedic Cell Therapy Market, U.S., 2016 78
Figure 4 14: Leading Competitors, Orthopedic Cell Therapy Market, U.S., 2016 81
Figure 6 1: Press Release Summary 85
MedtronicGenzymeDePuy SynthesAnika TherapeuticsFerring PharmaceuticalsStrykerNuVasiveBioventusZimmer BiometIntegra LifeSciencesRTI SurgicalFidia PharmaceuticalsMTFOrthofixArthrexAlloSourceAastromBaxterHarvest TechnologiesWright MedicalBacterin InternationalArteriocyteExactechLifeNet HealthBiocompositesAlphatec SpineCelling BiosciencesGlobus MedicalNuo TherapeuticsK2M*Not all companies are currently active in every segment or sub-report from this suite. For more details contact an iData Research Product Advisor.
