TABLE OF CONTENTS I
LIST OF FIGURES XVIII
LIST OF CHARTS XX
EXECUTIVE SUMMARY 1
U.S. ORTHOPEDIC BIOMATERIALS MARKET OVERVIEW 1
COMPETITIVE ANALYSIS 4
MARKET TRENDS 6
MARKET DEVELOPMENTS 8
PROCEDURE NUMBERS 9
MARKETS INCLUDED 11
KEY REPORT UPDATES 13
VERSION HISTORY 13
RESEARCH METHODOLOGY 14
1.1 RESEARCH SCOPE 14
1.2 IDATA’S 9-STEP METHODOLOGY 14
Step 1: Project Initiation & Team Selection 14
Step 2: Prepare Data Systems and Perform Secondary Research 16
Step 3: Preparation for Interviews & Questionnaire Design 17
Step 4: Performing Primary Research 18
Step 5: Research Analysis: Establishing Baseline Estimates 20
Step 6: Market Forecast and Analysis 21
Step 7: Identify Strategic Opportunities 23
Step 8: Final Review and Market Release 24
Step 9: Customer Feedback and Market Monitoring 25
DISEASE OVERVIEW 26
2.1 BASIC ANATOMY 26
2.1.1 Osteology and Musculoskeletal System 26
2.2 DISEASE PATHOLOGY AND DISORDERS 28
2.2.1 General Diagnostic 28
2.2.2 Osteoporosis 29
2.2.3 Osteoarthritis 29
2.2.4 Indication for Bone Graft Procedure 30
2.2.5 Indication for Cartilage Repair 31
2.2.6 Degenerative Disc Disease 32
2.3 PATIENT DEMOGRAPHICS 34
2.3.1 General Statistics 34
PRODUCT ASSESSMENT 36
3.1 PRODUCT PORTFOLIOS 36
3.1.1 Spinal Machined Bone Allografts 37
3.2 REGULATORY ISSUES AND RECALLS 40
3.2.1 Spinal Machined Bone Allografts 40
3.3 CLINICAL TRIALS 41
3.3.1 Spinal Machined Bone Allografts 41
SPINAL MACHINED BONE ALLOGRAFT MARKET 47
4.1 INTRODUCTION 47
4.1.1 Anterior Lumbar Interbody Fusion (ALIF) 48
4.1.2 Posterior Lumbar Interbody Fusion (PLIF) 48
4.1.3 Transforaminal Lumbar Interbody Fusion (TLIF) 48
4.1.3.1 Lateral Lumbar Interbody Fusion (LLIF) 48
4.1.3.2 Cervical Interbody Fusion (CIF) 49
4.1.4 Machined Bone Material 49
4.2 MARKET OVERVIEW 50
4.3 MARKET ANALYSIS AND FORECAST 53
4.3.1 Total Spinal Machined Bone Allograft Market 53
4.3.1.1 ALIF Machined Bone Allograft Market 55
4.3.1.2 PLIF Machined Bone Allograft Market 57
4.3.1.3 TLIF Machined Bone Allograft Market 59
4.3.1.4 CIF Machined Bone Allograft Market 61
4.4 DRIVERS AND LIMITERS 63
4.4.1 Market Drivers 63
4.4.2 Market Limiters 64
4.5 COMPETITIVE MARKET SHARE ANALYSIS 67
ABBREVIATIONS 71
APPENDIX II: COMPANY PRESS RELEASES 73

Chart 1 1: Orthopedic Biomaterials Market by Segment, U.S., 2013 – 2023 3
Chart 1 2: Orthopedic Biomaterials Market Overview, U.S., 2016 & 2023 3
Chart 4 1: Spinal Machined Bone Allograft Market by Segment, U.S., 2013 – 2023 51
Chart 4 2: Spinal Machined Bone Allograft Market Breakdown, U.S., 2016 52
Chart 4 3: Spinal Machined Bone Allograft Market Breakdown, U.S., 2023 52
Chart 4 4: Total Spinal Machined Bone Allograft Market, U.S., 2013 – 2023 54
Chart 4 5: ALIF Machined Bone Allograft Market, U.S., 2013 – 2023 56
Chart 4 6: PLIF Machined Bone Allograft Market, U.S., 2013 – 2023 58
Chart 4 7: TLIF Machined Bone Allograft Market, U.S., 2013 – 2023 60
Chart 4 8: CIF Machined Bone Allograft Market, U.S., 2013 – 2023 62
Chart 4 9: Leading Competitors, Spinal Machined Bone Allograft Market, U.S., 2016 70

Figure 1 1: Orthopedic Biomaterials Market Share Ranking by Segment, U.S., 2016 (1 of 2) 4
Figure 1 2: Orthopedic Biomaterials Market Share Ranking by Segment, U.S., 2016 (2 of 2) 4
Figure 1 3: Companies Researched in this Report, U.S., 2016 5
Figure 1 4: Factors Impacting the Orthopedic Biomaterials Market by Segment, U.S. (1 of 2) 6
Figure 1 5: Factors Impacting the Orthopedic Biomaterials Market by Segment, U.S. (2 of 2) 7
Figure 1 6: Recent Events in the Orthopedic Biomaterials Market, U.S., 2013 – 2016 8
Figure 1 7: Orthopedic Biomaterials Markets Covered, U.S., 2016 (1 of 2) 9
Figure 1 8: Orthopedic Biomaterials Markets Covered, U.S., 2016 (2 of 2) 10
Figure 1 9: Orthopedic Biomaterials Markets Covered, U.S., 2016(1 of 3) 11
Figure 3 1: Spinal Machined Bone Allograft Products by Company 39
Figure 3 2: Class 2 Device Recall Stryker Radius Spinal System 40
Figure 3 3: Study of Nucel for One and Two Level Lumbar Interbody Fusion 41
Figure 3 4: An ACDF Multi-Center Study Using ViviGen Cellular Bone Matrix 41
Figure 3 5: An Assessment of P-15 Bone Putty in Anterior Cervical Fusion With Instrumentation 42
Figure 3 6: Interbody Spacers With map3® Cellular Allogeneic Bone Graft in Anterior or Lateral Lumbar Interbody Fusion 42
Figure 3 7: Efficacy Study of NuCel® in Patients Undergoing Fusion of the Lumbar Spine 43
Figure 3 8: Prospective Study of Thoracolumbar Spinal Fusion Graft (BMAC) 43
Figure 3 9: Cellentra Viable Cell Bone Matrix (VCBM) Anterior Cervical Discectomy and Fusion Outcomes Study (VCBM/MaxAn) (VCBM/ACDF) 44
Figure 3 10: Prospective Study of Thoracolumbar Spinal Fusion Graft (BMAC) 44
Figure 3 11: PEEK and Allograft Spacers Evaluation in Spinal Fusion Surgeries (PEEK) 45
Figure 3 12: Restore CLINICAL TRIAL 45
Figure 3 13: A Prospective Study of NuCel® in Cervical Spine Fusion 46
Figure 3 14: Safety and Preliminary Efficacy Study of NeoFuse in Subjects Undergoing Multi-Level Anterior Cervical Discectomy 46
Figure 4 1: Spinal Machined Bone Allograft Market by Segment, U.S., 2013 – 2023 (US$M) 50
Figure 4 2: Total Spinal Machined Bone Allograft Market, U.S., 2013 – 2023 53
Figure 4 3: ALIF Machined Bone Allograft Market, U.S., 2013 – 2023 55
Figure 4 4: PLIF Machined Bone Allograft Market, U.S., 2013 – 2023 57
Figure 4 5: TLIF Machined Bone Allograft Market, U.S., 2013 – 2023 59
Figure 4 6: CIF Machined Bone Allograft Market, U.S., 2013 – 2023 61
Figure 4 7: Drivers and Limiters, Spinal Machined Bone Allograft Market, U.S., 2016 66
Figure 4 8: Leading Competitors, Spinal Machined Bone Allograft Market, U.S., 2016 69
Figure 6 1: Press Release Summary 73

Medtronic
Genzyme
DePuy Synthes
Anika Therapeutics
Ferring Pharmaceuticals
Stryker
NuVasive
Bioventus
Zimmer Biomet
Integra LifeSciences
RTI Surgical
Fidia Pharmaceuticals
MTF
Orthofix
Arthrex
AlloSource
Aastrom
Baxter
Harvest Technologies
Wright Medical
Bacterin International
Arteriocyte
Exactech
LifeNet Health
Biocomposites
Alphatec Spine
Celling Biosciences
Globus Medical
Nuo Therapeutics
K2M
*Not all companies are currently active in every segment or sub-report from this suite. For more details contact an iData Research Product Advisor.