General Report Contents
• Market Analyses include: Unit Sales, ASPs, Market Value & Growth Trends
• Market Drivers & Limiters for each chapter segment
• Competitive Analysis for each chapter segment
• Section on recent mergers & acquisitions
The market includes both bare platinum and coated coils. Coated coils grew in popularity after their initial release as they were thought to promote faster healing and a lower rate of recanalization in the aneurysm. In recent years clinical trials, such as MAPS and Cerecyte, failed to show superiority in clinical outcomes and as a result the use of coated coils has been decreasing. There has been a recent trend towards smaller aneurysms being treated, which require fewer coils, as they are getting diagnosed earlier in their development. Approximately five coils are used per aneurysm treatment for smaller aneurysms. When aneurysms are larger than 5 mm, there will be approximately two coils used per mm of aneurysm. Unit sales will also be threatened by new technology which will cannibalize aneurysm treatment procedures. As more aneurysms are treated by new technology and those remaining use fewer coils, there will be a decrease in unit sales.
The decrease in market value for coils will therefore be driven by both fewer unit sales and price decreases, with a shift away from the use of coated coils.
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TABLE OF CONTENTS I
LIST OF FIGURES X
LIST OF CHARTS XIII
EXECUTIVE SUMMARY 1
EUROPEAN NEUROMODULATION, NEUROVASCULAR, NEUROSURGICAL AND MONITORING DEVICE MARKET OVERVIEW 1
COMPETITIVE ANALYSIS 3
MARKET TRENDS 7
MARKET DEVELOPMENTS 10
MARKETS INCLUDED 11
PROCEDURES INCLUDED 12
KEY REPORT UPDATES 13
VERSION HISTORY 13
RESEARCH METHODOLOGY 14
1.1 RESEARCH SCOPE 14
1.2 IDATA’S 9-STEP METHODOLOGY 14
Step 1: Project Initiation & Team Selection 14
Step 2: Prepare Data Systems and Perform Secondary Research 16
Step 3: Preparation for Interviews & Questionnaire Design 17
Step 4: Performing Primary Research 18
Step 5: Research Analysis: Establishing Baseline Estimates 20
Step 6: Market Forecast and Analysis 21
Step 7: Identify Strategic Opportunities 23
Step 8: Final Review and Market Release 24
Step 9: Customer Feedback and Market Monitoring 25
DISEASE OVERVIEW 26
2.1 BASIC ANATOMY 26
2.2 DISEASE PATHOLOGY AND DISORDERS 28
2.2.1 Introduction 28
2.2.2 General Diagnostics and Neurosurgery 30
2.2.3 Tumor and Brain Cancer 32
2.2.4 Brain Arteriovenous Malformations 34
2.2.5 Ischemic Stroke 35
2.2.6 Brain Aneurysm 36
2.2.7 Disorders Related to Cerebrospinal Fluids and Intracranial Pressure 38
2.2.7.1 Hydrocephalus and Intracranial Pressure Disorder 38
2.2.7.2 Cerebral Edema 39
2.2.8 Indication for Neuromodulation 41
2.2.9 Traumatic brain injury 43
COUNTRY PROFILES 44
3.1 INTRODUCTION 44
3.1.1 Population 44
3.1.2 GDP Per Capita 44
3.1.3 Price Index 44
3.2 GERMANY 45
3.3 FRANCE 46
3.4 UNITED KINGDOM 47
3.5 ITALY 48
3.6 SPAIN 49
3.7 BENELUX 50
3.8 SCANDINAVIA 51
3.9 AUSTRIA 52
3.10 SWITZERLAND 53
3.11 PORTUGAL 54
PRODUCT ASSESSMENT 55
4.1 PRODUCT PORTFOLIOS 55
4.1.1 Detachable Coils 55
4.1.1.1 Introduction 55
4.1.1.2 Product Matrix for Detachable Coils Market: Core Companies 57
4.2 REGULATORY ISSUES AND RECALLS 58
4.2.1 Detachable Coils 58
4.3 CLINICAL TRIALS 61
4.3.1 Detachable Coils 61
DETACHABLE COIL MARKET 66
5.1 INTRODUCTION 66
5.2 MARKET OVERVIEW 67
5.3 MARKET ANALYSIS AND FORECAST 71
5.3.1 Total Detachable Coil Market 71
5.3.2 Bare Platinum Detachable Coil Market 78
5.3.3 Coated Detachable Coil Market 85
5.4 DRIVERS AND LIMITERS 92
5.4.1 Market Drivers 92
5.4.2 Market Limiters 93
5.5 COMPETITIVE MARKET SHARE ANALYSIS 96
ABBREVIATIONS 100
APPENDIX: COMPANY PRESS RELEASES 103
Chart 1 1: Neurological Device Market by Segment, Europe, 2013 – 2023 2
Chart 1 2: Neurological Device Market Overview, Europe, 2013 &2023 2
Chart 3 1: Country Profile, Germany, 2016 45
Chart 3 2: Country Profile, France, 2016 46
Chart 3 3: Country Profile, United Kingdom, 2016 47
Chart 3 4: Country Profile, Italy, 2016 48
Chart 3 5: Country Profile, Spain, 2016 49
Chart 3 6: Country Profile, Benelux, 2016 50
Chart 3 7: Country Profile, Scandinavia, 2016 51
Chart 3 8: Country Profile, Austria, 2016 52
Chart 3 9: Country Profile, Switzerland, 2016 53
Chart 3 10: Country Profile, Portugal, 2016 54
Chart 5 1: Detachable Coil Market by Segment, Europe, 2013 – 2023 69
Chart 5 2: Detachable Coil Market Breakdown, Europe, 2016 70
Chart 5 3: Detachable Coil Market Breakdown, Europe, 2023 70
Chart 5 4: Total Detachable Coil Market, Europe, 2013 – 2023 72
Chart 5 5: Bare Platinum Detachable Coil Market, Europe, 2013 – 2023 79
Chart 5 6: Coated Detachable Coil Market, Europe, 2013 – 2023 86
Chart 5 7: Leading Competitors, Detachable Coil Market, Europe, 2016 99
Figure 1 1: Neurological Device Market Share Ranking by Segment, Europe, 2016 (1 of 3) 4
Figure 1 2: Neurological Device Market Share Ranking by Segment, Europe, 2016 (2 of 3) 4
Figure 1 3: Neurological Device Market Share Ranking by Segment, Europe, 2016 (3 of 3) 5
Figure 1 4: Companies Researched in this Report, Europe, 2016 6
Figure 1 5: Factors Impacting the Neurological Device Market by Segment, Europe (1 of 3) 7
Figure 1 6: Factors Impacting the Neurological Device Market by Segment, Europe (2 of 3) 8
Figure 1 7: Factors Impacting the Neurological Device Market by Segment, Europe (3 of 3) 9
Figure 1 8: Recent Events in the Neurological Device Market, Europe, 2014 – 2016 10
Figure 1 9: Neurological Device Markets Covered, Europe, 2016 11
Figure 1 10: Neurological Device Procedures Covered, Europe, 2016 12
Figure 1 11: Key Report Updates 13
Figure 1 12: Version History 13
Figure 2 1: Neurology Disease Overview 29
Figure 2 2: Brain/Other Nervous System Cancer Statistics by Type and Gender, U.S., 2016 33
Figure 4 1: Class 2 Device Recall: Target Detachable Coils, Stryker Neurovascular 58
Figure 4 2: Class 2 Device Recall: GDC 360 Detachable Coil, Stryker Neurovascular 59
Figure 4 3: Class 2 Device Recall: Stryker Neurovascular 59
Figure 4 4: Class 2 Device Recall: GDC, Stryker Neurovascular 59
Figure 4 5: Class 3 Device Recall: Axium Detachable Coil System QC21Helix 60
Figure 4 6: Class 1 Device Recall: Penumbra Coil System, Penumbra Coil 400 60
Figure 4 7: Detachable Coils: Assessment of the Embolization of Neurovascular Lesions Using the Penumbra Smart Coil (SMART) 61
Figure 4 8: Detachable Coils: DELTA Trial: Does Embolization With Larger Coils Lead to Better Treatment of Aneurysms Trial 61
Figure 4 9: Detachable Coils: Framing Eighteen Coils in Cerebral Aneurysms Trial (FEAT) 62
Figure 4 10: Detachable Coils: Hydrogel Endovascular Aneurysm Treatment Trial (HEAT) 62
Figure 4 11: Detachable Coils: Prospective Packing Density With Target Coils I (PropackI) 62
Figure 4 12: Detachable Coils: COAST: Coiling of Aneurysms Smaller Than 5mm With Hypersoft® (COAST) 63
Figure 4 13: Detachable Coils: A Volumetric Coiling in Aneurysm Registry of the Penumbra Coil 400TM System in France (VOLCAN) 63
Figure 4 14: Detachable Coils: Study of the Penumbra Coil 400 System to Treat Aneurysm (ACE) 63
Figure 4 15: Detachable Coils: Hydrogel Balloon Assisted Intracranial Aneurysm Coiling Registry (GELATIN) 63
Figure 4 16: Detachable Coils: TARGET Intracranial Aneurysm Coiling Registry (TARGET) 64
Figure 4 17: Detachable Coils: HydroCoil Cerebral Aneurysm Treatment Trial (HCAT) 64
Figure 4 18: Detachable Coils: Evaluation of DeltaMaxx® Microcoil System in Intracranial Aneurysms 65
Figure 5 1: Detachable Coil Market by Segment, Europe, 2013 – 2023 (€M) 68
Figure 5 2: Detachable Coil Market by Segment, Europe, 2013 – 2023 (US$M) 68
Figure 5 3: Total Detachable Coil Market, Europe, 2013 – 2023 (€ and US$) 71
Figure 5 4: Units Sold by Country, Total Detachable Coil Market, Europe, 2013 – 2023 73
Figure 5 5: Average Selling Price by Country, Total Detachable Coil Market, Europe, 2013 – 2023 (€) 74
Figure 5 6: Average Selling Price by Country, Total Detachable Coil Market, Europe, 2013 – 2023 (US$) 75
Figure 5 7: Market Value by Country, Total Detachable Coil Market, Europe, 2013 – 2023 (€M) 76
Figure 5 8: Market Value by Country, Total Detachable Coil Market, Europe, 2013 – 2023 (US$M) 77
Figure 5 9: Bare Platinum Detachable Coil Market, Europe, 2013 – 2023 (€ and US$) 78
Figure 5 10: Units Sold by Country, Bare Platinum Detachable Coil Market, Europe, 2013 – 2023 80
Figure 5 11: Average Selling Price by Country, Bare Platinum Detachable Coil Market, Europe, 2013 – 2023 (€) 81
Figure 5 12: Average Selling Price by Country, Bare Platinum Detachable Coil Market, Europe, 2013 – 2023 (US$) 82
Figure 5 13: Market Value by Country, Bare Platinum Detachable Coil Market, Europe, 2013 – 2023 (€M) 83
Figure 5 14: Market Value by Country, Bare Platinum Detachable Coil Market, Europe, 2013 – 2023 (US$M) 84
Figure 5 15: Coated Detachable Coil Market, Europe, 2013 – 2023 (€ and US$) 85
Figure 5 16: Units Sold by Country, Coated Detachable Coil Market, Europe, 2013 – 2023 87
Figure 5 17: Average Selling Price by Country, Coated Detachable Coil Market, Europe, 2013 – 2023 (€) 88
Figure 5 18: Average Selling Price by Country, Coated Detachable Coil Market, Europe, 2013 – 2023 (US$) 89
Figure 5 19: Market Value by Country, Coated Detachable Coil Market, Europe, 2013 – 2023 (€M) 90
Figure 5 20: Market Value by Country, Coated Detachable Coil Market, Europe, 2013 – 2023 (US$M) 91
Figure 5 21: Drivers and Limiters, Detachable Coil Market, Europe, 2016 95
Figure 5 22: Leading Competitors, Detachable Coil Market, Europe, 2016 98
Figure 7 1: Press Release Summary 103
Medtronic
Stryker
Codman & Shurtleff, Inc.
St. Jude Medical
Nevro
Carl Zeiss
Boston Scientific
LivaNova
Terumo MicroVention
Penumbra Inc.
Leica
Integra LifeSciences
BrainLab
Balt
Magstim
Phenox
MagVenture
Elekta
Moëller Wedel
Misonix
Sophysa
Aesculap
MAG & More
Neurosoft
Acandis
Soring
Brainsway
Nexstim
Others include: ANT, Asahi Intecc, Axonics, Blockade, Dispomedica, Enteromedics, Flowonix, Inomed, Intrapace, Kaneka Medical Products, MHT, Micrus Endovascular, MRC, Navimetric, Neuravi, Neuronetics, Neuropace, NextGen Medicla System, Nuvectra, Scientia Vascular, Spiegelberg, Stimwave, Tokai Medical Product, Tricumed, Vascular Solutions, etc.
