Summary
Estrogen Receptor Beta (ER Beta or Nuclear Receptor Subfamily 3 Group A Member 2 or NR3A2 or ESR2) pipeline Target constitutes close to 19 molecules. Out of which approximately 14 molecules are developed by companies and remaining by the universities/institutes. The latest report Estrogen Receptor Beta - Drugs In Development, 2022, outlays comprehensive information on the Estrogen Receptor Beta (ER Beta or Nuclear Receptor Subfamily 3 Group A Member 2 or NR3A2 or ESR2) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
Estrogen Receptor Beta (ER Beta or Nuclear Receptor Subfamily 3 Group A Member 2 or NR3A2 or ESR2) - Estrogen receptor beta (ERB) is a nuclear receptor that is activated by the sex hormone estrogen. It is encoded by the gene ESR2. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. The molecules developed by companies in Pre-Registration, Phase II, Phase I and Preclinical stages are 1, 5, 2 and 6 respectively. Similarly, the universities portfolio in Phase II, Preclinical and Discovery stages comprises 1, 2 and 2 molecules, respectively. Report covers products from therapy areas Oncology, Central Nervous System, Women's Health, Musculoskeletal Disorders, Genetic Disorders, Hormonal Disorders, Immunology, Infectious Disease, Male Health, Metabolic Disorders and Respiratory which include indications Multiple Sclerosis, Alzheimer's Disease, Breast Cancer, Osteoporosis, Prostate Cancer, Vasomotor Symptoms of Menopause (Hot Flashes), Acid Sphingomyelinase Deficiency (Niemann-Pick Disease) Type C, Acute Respiratory Distress Syndrome, Bile Duct Cancer (Cholangiocarcinoma), Carcinomas, Colon Cancer, Coronavirus Disease 2019 (COVID-19), Dementia, Demyelinating Diseases, Depression, Endometrial Cancer, Fallopian Tube Cancer, Hormone Sensitive Breast Cancer, Human Epidermal Growth Factor Receptor 2 Negative Breast Cancer (HER2- Breast Cancer), Inflammation, Leiomyosarcoma, Male Hypogonadism, Malignant Pleural Mesothelioma, Neuromyelitis Optica (Devic’s Syndrome), Obesity, Ovarian Cancer, Peritoneal Cancer, Post Menopausal Mood Disorder, Precocious Puberty, Triple-Negative Breast Cancer (TNBC) and Uterine Cancer.
Furthermore, this report also reviews key players involved in Estrogen Receptor Beta (ER Beta or Nuclear Receptor Subfamily 3 Group A Member 2 or NR3A2 or ESR2) targeted therapeutics development with respective active and dormant or discontinued projects. Driven by data and information sourced from proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources.
Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.
Scope
- The report provides a snapshot of the global therapeutic landscape for Estrogen Receptor Beta (ER Beta or Nuclear Receptor Subfamily 3 Group A Member 2 or NR3A2 or ESR2)
- The report reviews Estrogen Receptor Beta (ER Beta or Nuclear Receptor Subfamily 3 Group A Member 2 or NR3A2 or ESR2) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
- The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
- The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
- The report reviews key players involved in Estrogen Receptor Beta (ER Beta or Nuclear Receptor Subfamily 3 Group A Member 2 or NR3A2 or ESR2) targeted therapeutics and enlists all their major and minor projects
- The report assesses Estrogen Receptor Beta (ER Beta or Nuclear Receptor Subfamily 3 Group A Member 2 or NR3A2 or ESR2) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
- The report summarizes all the dormant and discontinued pipeline projects
- The report reviews latest news and deals related to Estrogen Receptor Beta (ER Beta or Nuclear Receptor Subfamily 3 Group A Member 2 or NR3A2 or ESR2) targeted therapeutics
Reasons to Buy
- Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
- Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
- Identify and understand the targeted therapy areas and indications for Estrogen Receptor Beta (ER Beta or Nuclear Receptor Subfamily 3 Group A Member 2 or NR3A2 or ESR2)
- Identify the use of drugs for target identification and drug repurposing
- Identify potential new clients or partners in the target demographic
- Develop strategic initiatives by understanding the focus areas of leading companies
- Plan mergers and acquisitions effectively by identifying key players and it’s most promising pipeline therapeutics
- Devise corrective measures for pipeline projects by understanding Estrogen Receptor Beta (ER Beta or Nuclear Receptor Subfamily 3 Group A Member 2 or NR3A2 or ESR2) development landscape
- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope
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Table of Contents
List of Tables
List of Figures
Introduction
Global Markets Direct Report Coverage
Estrogen Receptor Beta (ER Beta or Nuclear Receptor Subfamily 3 Group A Member 2 or NR3A2 or ESR2) - Overview
Estrogen Receptor Beta (ER Beta or Nuclear Receptor Subfamily 3 Group A Member 2 or NR3A2 or ESR2) - Therapeutics Development
Products under Development by Stage of Development
Products under Development by Therapy Area
Products under Development by Indication
Products under Development by Companies
Products under Development by Universities/Institutes
Estrogen Receptor Beta (ER Beta or Nuclear Receptor Subfamily 3 Group A Member 2 or NR3A2 or ESR2) - Therapeutics Assessment
Assessment by Mechanism of Action
Assessment by Route of Administration
Assessment by Molecule Type
Estrogen Receptor Beta (ER Beta or Nuclear Receptor Subfamily 3 Group A Member 2 or NR3A2 or ESR2) - Companies Involved in Therapeutics Development
AstraZeneca Plc
Avivia BV
Eagle Pharmaceuticals Inc
Eli Lilly and Co
Endece LLC
Endoceutics Inc
Estrigenix Therapeutics Inc
Helixmith Co Ltd
Karo Pharma AB
Kissei Pharmaceutical Co Ltd
MEI Pharma Inc
Vivesto AB
Estrogen Receptor Beta (ER Beta or Nuclear Receptor Subfamily 3 Group A Member 2 or NR3A2 or ESR2) - Drug Profiles
acolbifene + prasterone - Drug Profile
Product Description
Mechanism Of Action
acolbifene hydrochloride - Drug Profile
Product Description
Mechanism Of Action
AUS-131 - Drug Profile
Product Description
Mechanism Of Action
History of Events
dehydrodiconiferyl alcohol - Drug Profile
Product Description
Mechanism Of Action
History of Events
Drug to Agonize ER-Beta for Multiple Sclerosis - Drug Profile
Product Description
Mechanism Of Action
EGX-358 - Drug Profile
Product Description
Mechanism Of Action
History of Events
erteberel - Drug Profile
Product Description
Mechanism Of Action
History of Events
estradiol - Drug Profile
Product Description
Mechanism Of Action
History of Events
fosfestrol - Drug Profile
Product Description
Mechanism Of Action
fulvestrant - Drug Profile
Product Description
Mechanism Of Action
History of Events
fulvestrant - Drug Profile
Product Description
Mechanism Of Action
History of Events
KB-3944 - Drug Profile
Product Description
Mechanism Of Action
KB-9520 - Drug Profile
Product Description
Mechanism Of Action
History of Events
Libidua - Drug Profile
Product Description
Mechanism Of Action
Loseasonique - Drug Profile
Product Description
Mechanism Of Action
History of Events
NDC-1308 - Drug Profile
Product Description
Mechanism Of Action
History of Events
Small Molecule to Agonize ESR2 for Obesity and Depression - Drug Profile
Product Description
Mechanism Of Action
History of Events
Small Molecule to Agonize ESR2 for Oncology - Drug Profile
Product Description
Mechanism Of Action
History of Events
Small Molecules to Agonize ESR2 for Multiple Sclerosis - Drug Profile
Product Description
Mechanism Of Action
History of Events
Small Molecules to Agonize Estrogen Beta Receptor for Inflammatory Diseases and Oncology - Drug Profile
Product Description
Mechanism Of Action
History of Events
Estrogen Receptor Beta (ER Beta or Nuclear Receptor Subfamily 3 Group A Member 2 or NR3A2 or ESR2) - Dormant Products
Estrogen Receptor Beta (ER Beta or Nuclear Receptor Subfamily 3 Group A Member 2 or NR3A2 or ESR2) - Discontinued Products
Estrogen Receptor Beta (ER Beta or Nuclear Receptor Subfamily 3 Group A Member 2 or NR3A2 or ESR2) - Product Development Milestones
Featured News & Press Releases
Dec 03, 2020: AstraZeneca presents new data on fulvestrant at the 2020 San Antonio Breast Cancer Symposium (SABCS)
May 04, 2020: Eagle Pharmaceuticals advances novel and proprietary formulation of Fulvestrant product candidate EA-114; company to request additional meeting with U.S. Food and Drug Administration
Dec 09, 2019: Eagle Pharmaceuticals commences dosing in pilot study for novel estrogen receptor antagonist product candidate
Aug 05, 2019: Eagle Pharmaceuticals announces Clinical Development Plan of innovative product intended to deliver maximum Estrogen Receptor inhibition in patients with Estrogen Receptor (ER)-Positive Breast Cancer
Mar 27, 2019: Combo better for HR+ breast cancer patients
Oct 30, 2018: Eagle Pharmaceuticals announces results of study for fulvestrant
Oct 20, 2018: New option for women with advanced breast cancer resistant to hormone therapy
Oct 04, 2018: Mayo researchers identify potential new treatment for subset of women with triple-negative breast cancer
Jun 01, 2018: ENDECE Attending 2018 Bio International in Boston
Mar 26, 2018: Mayne Pharma Launches Generic Quartette in the U.S., Another Womens Health Product
Dec 11, 2017: AstraZeneca’s Faslodex Rejects For Use Within NHS Scotland
Dec 07, 2017: Eagle Pharmaceuticals Commences Pivotal Study for Fulvestrant
Nov 15, 2017: Faslodex receives US FDA approval for the treatment of advanced breast cancer in combination with abemaciclib
Nov 14, 2017: Faslodex (Fulvestrant) Receives EU Approval for the Treatment of Hormone Receptor-Positive Advanced Breast Cancer in Combination with Palbociclib
Oct 13, 2017: Faslodex (Fulvestrant) Receives Positive CHMP Opinion For The Treatment Of Hormone Receptor-Positive Advanced Breast Cancer In Combination With Palbociclib
Appendix
Methodology
Coverage
Secondary Research
Primary Research
Expert Panel Validation
Contact Us
Disclaimer
List of Tables
Number of Products under Development by Stage of Development, 2022
Number of Products under Development by Therapy Areas, 2022
Number of Products under Development by Indications, 2022
Number of Products under Development by Companies, 2022
Products under Development by Companies, 2022
Products under Development by Companies, 2022 (Contd..1)
Number of Products under Investigation by Universities/Institutes, 2022
Products under Investigation by Universities/Institutes, 2022
Number of Products by Stage and Mechanism of Actions, 2022
Number of Products by Stage and Route of Administration, 2022
Number of Products by Stage and Molecule Type, 2022
Pipeline by AstraZeneca Plc, 2022
Pipeline by Avivia BV, 2022
Pipeline by Eagle Pharmaceuticals Inc, 2022
Pipeline by Eli Lilly and Co, 2022
Pipeline by Endece LLC, 2022
Pipeline by Endoceutics Inc, 2022
Pipeline by Estrigenix Therapeutics Inc, 2022
Pipeline by Helixmith Co Ltd, 2022
Pipeline by Karo Pharma AB, 2022
Pipeline by Kissei Pharmaceutical Co Ltd, 2022
Pipeline by MEI Pharma Inc, 2022
Pipeline by Vivesto AB, 2022
Dormant Products, 2022
Dormant Products, 2022 (Contd..1)
Dormant Products, 2022 (Contd..2)
Dormant Products, 2022 (Contd..3)
Discontinued Products, 2022
List of Figures
Number of Products under Development by Stage of Development, 2022
Number of Products under Development by Therapy Areas, 2022
Number of Products under Development by Top 10 Indications, 2022
Number of Products by Mechanism of Actions, 2022
Number of Products by Stage and Mechanism of Actions, 2022
Number of Products by Routes of Administration, 2022
Number of Products by Stage and Routes of Administration, 2022
Number of Products by Stage and Molecule Type, 2022
